When an unassuming high school chemistry teacher discovers he has a rare form of lung cancer, he decides to team up with a former student and create a top of the line crystal meth in a used RV, to provide for his family once he is gone.

Walter is in a mess along with Jesse as they are not able to successfully dispose of the mess from their RV. Complications reach its peak when Skyler, Walter's wife develops a doubt on her husband mysterious actions as he suddenly behaves obnoxiously. Moreover, she tries to look out in the matter starting from his laptop.

Walter fights with Jesse over his drug use, causing him to leave Walter alone with their captive, Krazy-8. Meanwhile, Hank has a scared straight moment with Walter Jr. after his aunt discovers he has been smoking pot. Also, Skylar is upset when Walter stays away from home.

Walter finally tells his family that he has been stricken with cancer. Meanwhile, the DEA believes Albuquerque has a new, big time player to worry about. Meanwhile, a worthy recipient is the target of a depressed Walter’s anger, and Jesse makes a surprise visit to his parents home.

Walter is offered a new job while attending a birthday party for a successful former science colleague. Jesse finds himself unsuccessful at finding a legitimate job and ends up back to cooking up meth, and an inferior product at that. Skyler tries to get Walter into chemotherapy by gathering his family for an intervention, but he is worried about their financial difficulties and what his quality of life will be like.

Walter cooks up even more crystal meth than ever with Jesse as he needs money for his chemotherapy treatments. Meanwhile, Skinny Pete gives Jesse a new important contact, as the DEA beefs up its investigation of Albuquerque's new drug kingpin.

Production problems arise immediately as Walter and Jesse do business with a new partner in crime, causing them to attempt to steal from a chemical supply house. Meanwhile, Marie shows a different side of herself as she throws Skylar a baby shower and gives her an unusual gift.